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January 28th, 2008 Posted by: admin
Obesity and Acomplia (Rimonabant)
Obesity is now the most common nutritional disorder in western industrialised countries. Defined as a body mass index of greater than 30, it arises from the accumulation of excess fat in the body from over consumption of fatty foods. Prevalence of obesity in the US and Europe has reached epidemic levels.Data from the World Health Organisation’s MONICA project show that in some parts of Europe over 70% of men aged 55-64 years are clinically obese or overweight (BMI >25) and almost 70% of women in this age group. One in five of all Americans is obese and one in three overweight. Furthermore, increasing rates of childhood obesity are likely to exacerbate the trend towards increasing obesity in adulthood.There is a strong association between obesity and increased risk of cardiovascular disease and diabetes and possibly certain cancers, such as breast and colorectal cancer [buy acomplia online].The dramatic rise in the incidence of type 2 diabetes is due largely to the increased prevalence of obesity. Increases in body weight lead to changes in blood lipid and cholesterol levels, predisposing to increased risk of atherosclerosis.The promising preclinical findings with Acomplia (rimonabant) have been confirmed in a series of clinical studies, including pivotal phase III trials involving over 6,000 obese subjects that were carried out in both the US and Europe.Two-year data from the phase III multicentre Rimonabant In Obesity (RIO) trials, which compared rimonabant at doses of 5mg and 20mg with placebo with respect to weight reduction and prevention of weight gain, showed that the positive results seen after a year’s treatment were sustained over the full two-year trial period [buy acomplia online].
Consistent with the one-year data, the results showed that overweight and obese patients taking rimonabant 20mg/d achieved significant reductions in body weight, waist circumference (an indicator of abdominal obesity) and improved lipid and glycaemic profiles compared with placebo recipients. Rimonabant also had a significant impact on metabolic CVD risk factors, greater than that expected by weight loss alone.Efficacy and safety in long-term use is important feature of any antiobesity drug. Some potential antiobesity medications have proved effective in the first six months of treatment only to lose effectiveness as subjects develop resistance to treatment.Data from the RIO trials suggest acomplia is effective for maintaining weight loss for periods of at least two years. Long-term safety is also a major concern. In the US, the FDA generally requires two years of safety data before approving antiobesity drugs [buy acomplia online].Results from the phase III RIO trial programme suggest rimonabant is well tolerated in long-term use. Among patients who were randomly assigned to continue their first-year treatment for a second year, 6.7%, 8.3% and 6.0% discontinued from the placebo, rimonabant 5mg and 20mg groups respectively.The ongoing phase IIIb trial programme for rimonabant includes studies in patients with diabetes (SERENADE), dyslipidaemia (ADAGIO) and cardiovascular disease (STRADIVARIUS, AUDITOR, CRESCENDO). f you take the diet drug Acomplia, you can keep off lost pounds only if you keep taking it, researchers say.
And those who stay on the drug keep their smaller waist, lower blood-fat levels, and higher good cholesterol levels.
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If you don’t cut your calories, Acomplia won’t help you lose weight. But obese and overweight people who do eat less lost an average of 14 pounds if they were able to take Acomplia for one year. That’s 10.5 pounds more than those who ate less and got an inactive placebo pill, reports F. Xavier Pi-Sunyer, MD, professor of medicine at Columbia University and chief of endocrinology at St. Luke’s-Roosevelt Hospital, New York.”I think it is exciting, because [Acomplia] has a new mechanism of action, and seems as effective [for weight loss] as any drug on the market,” Pi-Sunyer tells WebMD. “[Acomplia] does a reasonable job of modest weight loss.”The results, first reported in 2004, appear in the Feb. 15 issue of The Journal of the American Medical Association.The FDA has not yet approved Acomplia, but is expected to act soon. In clinical trials, the drug has helped people lose weight. Obese people seem to have an overactive cannabinoid system. By partially shutting this system down, Acomplia helps people resist the craving for highly palatable food popularly known as ‘the munchies.’
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By failing to include those who stopped taking the drug, the study gives a rosier-than-real-life picture of Acomplia benefits, says Denise G. Simons-Morton, MD, PhD, director of the clinical applications and prevention program at the National Heart, Lung, and Blood Institute [buy acomplia online].”The real question is how useful Acomplia will be in a broad group of people, who may begin taking it and stop. It is not the whole picture, to look just at the people who keep taking it,” Simons-Morton tells WebMD. “Until we have studies with a more rigorous design, we don’t know yet how much of a benefit it would be for people trying to lose weight.”An editorial by Simons-Morton and colleagues accompanies the Pi-Sunyer report in JAMA. The editorial calculates that if one accepts Pi-Sunyer and colleagues’ results, taking Acomplia helps people lose 4.5% of their body weight.
